Talk:Choline

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Choline Storagel

I'm trying to make a case for evolution. I'm trying to locate information on where choline is stored in the human body. According to the NIH health professional fact sheet for choline, choline is stored in the human liver. I would believe most choline in the human body is stored in the human intestines and some in the kidneys along with the liver. I'm looking for this information online, but am having difficulty finding it. I know that animal intestines are composed of a large percentage of choline. Same with other organ meats. I just need some nutrition text book or verifiable research that can be posted as a reference to show that the vitamin like substance free choline is stored in the human intestines or phosphatidylcholine choline for that matter. If you find this information, could you please add this detailed information on the choline page. Thank you! 69.176.9.135 (talk) 15:32, 11 February 2023 (UTC)[reply]

From the National Institutes of Health, "Free choline, phosphocholine, and glycerophosphocholine are absorbed in the small intestine, enter the portal circulation, and are stored in the liver, where they are subsequently phosphorylated and distributed throughout the body to make cell membranes". It is probably worth adding this reference to the article [1]. Psychologist Guy (talk) 20:24, 11 February 2023 (UTC)[reply]

Another source "Choline is stored in tissues either as membrane-bound phospholipids or as intracellular PC or GPC. Choline is stored in the brain as membrane-bound phospholipids, which are hydrolysed by choline acetyltransferase to provide choline for acetylcholine synthesis. [2] Psychologist Guy (talk) 20:37, 11 February 2023 (UTC)[reply]

Sources in the intro

The intro needs better sources for the claim "essential".

The HMDB is a company that earns money with analyzing metabolites. It claims choline "is now an essential vitamin" but does not give any sources. The company does profit from declaring insufficient metabolization and providing means to check the metabolization.

While the LPI does provide sources, it did not read them carefully it seems as the authors cite a review sponsored by the Egg Board and Beef Checkoff (Wallace TC 2018) to claim that vegetarians are at risk of deficiency. Blausonorisch (talk) 06:55, 31 October 2024 (UTC)[reply]

Thank you. I will work on sourcing. The objectivity and scholarship of LPI always worries me.--Smokefoot (talk) 16:07, 31 October 2024 (UTC)[reply]